Journal article
CSF-1 Receptor-Dependent Colon Development, Homeostasis and Inflammatory Stress Response
D Huynh, D Akçora, J Malaterre, CK Chan, XM Dai, I Bertoncello, ER Stanley, RG Ramsay
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) directly regulates the development of Paneth cells (PC) and influences proliferation and cell fate in the small intestine (SI). In the present study, we have examined the role of CSF-1 and the CSF-1R in the large intestine, which lacks PC, in the steady state and in response to acute inflammation induced by dextran sulfate sodium (DSS). As previously shown in mouse, immunohistochemical (IHC) analysis of CSF-1R expression showed that the receptor is baso-laterally expressed on epithelial cells of human colonic crypts, indicating that this expression pattern is shared between species. Colons from Csf1r null and Csf1op/op mice were isola..
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia Program # 487922, the Cancer Council of Victoria project grant #400217 (R.R.), National Institutes of Health grant CA32551 (E.R.S), the Albert Einstein College of Medicine Cancer Center grant 5P30-CA13330, an American Society of Hematology Fellow Scholar Award (X-M. D.) and a Leukaemia and Lymphoma Society Special Fellow Award (X-M.D). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.